	   SnapGene      nCAACTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGTCGACCATAGCCAATTCAATATGGCGTATATGGACTCATGCCAATTCAATATGGTGGATCTGGACCTGTGCCAATTCAATATGGCGTATATGGACTCGTGCCAATTCAATATGGTGGATCTGGACCCCAGCCAATTCAATATGGCGGACTTGGCACCATGCCAATTCAATATGGCGGACTTGGCACTGTGCCAACTGGGGAGGGGTCTACTTGGCACGGTGCCAAGTTTGAGGAGGGGTCTTGGCCCTGTGCCAAGTCCGCCATATTGAATTGGCATGGTGCCAATAATGGCGGCCATATTGGCTATATGCCAGGATCAATATATAGGCAATATCCAATATGGCCCTATGCCAATATGGCTATTGGCCAGGTTCAATACTATGTATTGGCCCTATGCCATATAGTATTCCATATATGGGTTTTCCTATTGACGTAGATAGCCCCTCCCAATGGGCGGTCCCATATACCATATATGGGGCTTCCTAATACCGCCCATAGCCACTCCCCCATTGACGTCAATGGTCTCTATATATGGTCTTTCCTATTGACGTCATATGGGCGGTCCTATTGACGTATATGGCGCCTCCCCCATTGACGTCAATTACGGTAAATGGCCCGCCTGGCTCAATGCCCATTGACGTCAATAGGACCACCCACCATTGACGTCAATGGGATGGCTCATTGCCCATTCATATCCGTTCTCACGCCCCCTATTGACGTCAATGACGGTAAATGGCCCACTTGGCAGTACATCAATATCTATTAATAGTAACTTGGCAAGTACATTACTATTGGAAGGACGCCAGGGTACATTGGCAGTACTCCCATTGACGTCAATGGCGGTAAATGGCCCGCGATGGCTGCCAAGTACATCCCCATTGACGTCAATGGGGAGGGGCAATGACGCAAATGGGCGTTCCATTGACGTAAATGGGCGGTAGGCGTGCCTAATGGGAGGTCTATATAAGCAATGCTCGTTTAGGGAACCGCCATTCTGCCTGGGGACGTCGGAGCAAGCTTGATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGGATCCatgtcgaagccccatagtgaagccgggactgccttcattcagacccagcagctgcacgcagccatggctgacacattcctggagcacatgtgccgcctggacattgattcaccacccatcacagcccggaacactggcatcatctgtaccattggcccagcttcccgatcagtggagacgttgaaggagatgattaagtctggaatgaatgtggctcgtctgaacttctctcatggaactcatgagtaccatgcggagaccatcaagaatgtgcgcacagccacggaaagctttgcttctgaccccatcctctaccggcccgttgctgtggctctagacactaaaggacctgagatccgaactgggctcatcaagggcagcggcactgcagaggtggagctgaagaagggagccactctcaaaatcacgctggataacgcctacatggaaaagtgtgacgagaacatcctgtggctggactacaagaacatctgcaaggtggtggaagtgggcagcaagatctacgtggatgatgggcttatttctctccaggtgaagcagaaaggtgccgacttcctggtgacggaggtggaaaatggtggctccttgggcagcaagaagggtgtgaaccttcctggggctgctgtggacttgcctgctgtgtcggagaaggacatccaggatctgaagtttggggtcgagcaggatgttgatatggtgtttgcgtcattcatccgcaaggcatctgatgtccatgaagttaggaaggtcctgggagagaagggaaagaacatcaagattatcagcaaaatcgagaatcatgagggggttcggaggtttgatgaaatcctggaggccagtgatgggatcatggtggctcgtggtgatctaggcattgagattcctgcagagaaggtcttccttgctcagaagatgatgattggacggtgcaaccgagctgggaagcctgtcatctgtgctactcagatgctggagagcatgatcaagaagccccgccccactcgggctgaaggcagtgatgtggccaatgcagtcctggatggagccgactgcatcatgctgtctggagaaacagccaaaggggactatcctctggaggctgtgcgcatgcagcacctgatagctcgtgaggctgaggcagccatgttccaccgcaagctgtttgaagaacttgtgcgagcctcaagtcactccacagacctcatggaagccatggccatgggcagcgtggaggcttcttataagtgtttagcagcagctttgatagttctgacggagtctggcaggtctgctcaccaggtggccagataccgcccacgtgcccccatcattgctgtgacccggaatccccagacagctcgtcaggcccacctgtaccgtggcatcttccctgtgctgtgcaaggacccagtccaggaggcctgggctgaggacgtggacctccgggtgaactttgccatgaatgttggcaaggcccgaggcttcttcaagaagggagatgtggtcattgtgctgaccggatggcgccctggctccggcttcaccaacaccatgcgtgttgttcctgtgccgGAATTCGACTACAAAGACCATGACGGTGATTATAAAGATCATGACATCGATTACAAGGATGACGATGACAAGtgaCTCGAGCCTCTAGAACTATAGTGAGTCGTATTACGTAGATCCAGACATGATAAGATACATTGATGAGTTTGGACAAACCACAACTAGAATGCAGTGAAAAAAATGCTTTATTTGTGAAATTTGTGATGCTATTGCTTTATTTGTAACCATTATAAGCTGCAATAAACAAGTTAACAACAACAATTGCATTCATTTTATGTTTCAGGTTCAGGGGGAGGTGTGGGAGGTTTTTTAATTCGCGGCCGCGGCGCCAATGCATTGGGCCCGGTACCCAGCTTTTGTTCCCTTTAGTGAGGGTTAATTGCGCGCTTGGCGTAATCATGGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGGACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCGCCGCTACAGGGCGCGTCCCATTCGCCATTCAGGCTGCG  2Ý                  #         !            %                        '                                    !                     
                                                    &         $      /                        !                                 '            !   -         "             
            0                  #      '               !            	                  
                              $      7            !                         #         
                                                       	                                       
      	      %   "                                                                                       #   !      *      !      $                  #                                       #               	             -                                      õ ú ª¯Ü˜™­¶·zçiYkŒÍ  ö Ï«éx÷enÀ ®J
¸ÁºèjgB±é´Îí û ÑVÌš

{Ã1l	�   ô]°ÀÕËÖ]vÀÝ`9	
èý¯rZñK_	O ÷ ¬ê"°^ëø¨ùf ³@†ž»B	o	ü	K
¹Âéµü# 	 Jß)J|W®[o!*	³	˜
d»uš h�.n²KÒêú©Ïéî h ¤ jÐZo Á‚c
Ñ
kM&ýC^jD P n Œ ª Â à ·NyÂ¹<çÿ¯ð	

*q;!  e ¡ 
F3èQT‡”¢«µÍ,ÈÒ‡	
±
¼|ñ—@VÐ÷ÓÄ” ŽWzÙî;PŠàú5|©Ê
 ¢Ò›£°ÅñXÓT“2m
 ü ø9Faí_òz	S
&&�J¦ƒaŽ%  G ƒ ¿ Ý Rõ^swÁÖÝg
Úîþ4M³ôp=/û[òL`×à
P È æ Aw8_±ç×Ý^ÁDÛhå:	v	Ù	0
¸Åï™Öâ ^–žÔ‹¡4©Ì8w¸ÞËa¾ßE	
<
o
u
.Á°dLf  #U†�´•�ùœ¶s3	Š	É	ÿ	5
ÔéÜŠ•§Y#s~Øf ø ­ëæ©–¡´¼ÝãC	ý		
:
ºÃìï3Ã’ _¿+úgi�áíAŸL
êP<ìzã Sp	ú
$†ïI¤œº2Ö& #±ìùC‡	ç
_Š7‚Ò/wÇ@¶Äý' 
 KerñôXŠÉüT\kï"Oe	+	G
e!iQn�o~³tÓ$êï }�¯p«¡CW;¼v÷žõ3L^û[�ÜOÐåòø <?*.j�´	)
™
:×cîëPú à=KÆ-EÒt	
ð
z›¼/4 5rªÚ Ñˆps!K¨½:nƒN
d
Ò
Ø
!`Â†c ä'Óc	�	lN4E -É}ã
´
É
'êDRS¾  i ¥ k[Áf	ÂÕI½
	³þ	_kÔ);ik|  Þ0Sj‚­ÆüOn¡·Ì(¥l	
®
Õ
Ïâ$Ê 6¥Ã° ½	Ã
Û
+þÿr«õ Q � Ã á z=šèŒ°Ÿ
â
ôÏ< 3 o « ¸‰aŒº"	®	ñ	
_
¨
=Î>þÿ! f ¢ 2§é6RU[m¬¶åÉÐq@	ˆ	×	
Q
¿ònTWÑ,�õ9Þ 4p&ˆ£Ð»ÓlÛ¬	
²
à
ø
AU^9ˆ€ÁÍÔÅp $Îô-Q	ˆ
½7o˜´ÿø…ó  t ’ ì )Gà¹n•0Â
	›	å	ê	Z
“
}Æ,¶A*H?”†• áÚ‡š:ªËÀ �	1{ÏrqQ áû ž¼w¾‰”š) J † ¯Ämÿ
ø<‹6v}”õT
 =Xc”ñUÒ	ïØ  ¡$-
Š
Ÿ­¦í«ÝàEm{w  W�AY”=¯Ë4U‡”3š¥±¼ Ó/¤ýS	&ªÆ0ò¶ÔÜ‚Ò½… £êÄNœîg	�
±ü*8“¡ÅKâÃ R‚n 0 böü
·Ã'žü� 3V…°Éÿq¤5)	Å	T
'ëKúp²äE ý :Gî%9óšr	{	ê §Ù 9W 0ùbN`}÷	Uñ„b(U  À Þ Sö_x×\ÛÒØåï29N>ÎRùBÿ  †	5õ1Ò:0ü\óMaØáö H „ ÂÞ3>	†
�ö«´l»˜¯'S tpÄh
Û¢ãÿ .qÕƒðyÖ's%;DQ  `W�™Øã_�ÂêizÊæ;	X	[	w	>r,äçò{‚š1 x9²ºø%MbÅ@…öì	1
‚„�¹à/\‰ØJÉ×áã BèEÜE�ÆÚ	�ãhÏÔð¢¨' É ç •³rÞÍ¸Æ�–uŸ& Œ’¢¤î9ßâñ=b—¿àú©	ç	
\
-Ì/°„¬±ÒŠÇ,t"g $ _—G2cŒCe¶éI )ÿ�†xF	^	=
v
Liö¯	Fs¸ÅÆ=$ ŸÕý5ªÍ¹Ìü×	Á	p
H¤"BÂå$0~¥…­'EMÿYAÅ u»—‰•
Õa¨Ckt®ÞÙ—Ô8F/ , : X v ” ² Ð î +4IVfŽž¼"R�œwû·t§é.	4	‹	$
ÝÈÝ‹–�gÇã·)ˆ^  všâ~¾í%	 
é
vY×Zð• $‡µè–¦Üò‚hÛú�RW•	�	Ê	6
j
ê«ÇÊ$g¸  ù U®ÕöËm—¬I
µ	hAqèð0jJ^³ìN i¶MY¸þZï	û	

Ð
t™%pü]iÑèû ¡ì2çP†“ª^¢ñy	†	¯»Äð‰œ4“ vÜCµÚg½ÞäD	È	þ	4
;
íL‰”¦À<Äî.Õ×e åhìBëî.H£¹%Ã! >ió,D�ÈûjsŽî N 	F
ï
9bymô}sí3Zù4äñ ãÀe|â9Ž	M
¼
éQjRÁ{ ˆ`¯!	¼	§
þ=þ o
#ZºkP	ß
÷
@n‡S+À)€„ò>… Ã0<b“Tu“�»¿v× Vf	%Œ’J“¥�®ìÂÊÑ3z�„ / /$|	q	ö	û
¶êðŸã' Ú=	8k0ÍÑxQºA—õþ ÷$Ž²aŒÄ„DÌW	Z	gƒŽÓ+ãæ[œ0§È&ž (F‘þ€íÖù]	À	~õ,‹ËA#}«¬µXÄÅ 9 ± ç!gt›Úvú$Qˆ¦è	-	è
`uÉ�fj·Ó'  L·ÔõO’ÊýB]lðf«î	3
H
Ï
Kˆ“¥oû@\p-hÔçïI²çëú hòCdÇr{M	E
¦
»
x
ý¢Àø$3ð .;’#"YU	O	Þ
‹méR€’¾uyâ=„ƒ ö'Efs‹#Pø,	}ft"jªŽâ´P%–�Òô! ~¶!‘qª¥
º
lsJw‡’¤	¡ú[‘O<æƒ÷2Hœ±Ñæóù-  °‡DEFG†‘¢£ÛÜŸ ö÷øù4YZyzLMN;M_ËÌÙãäå\]‚¨åöPQ ‘}¼Ñ±ˆ¬HX<Ýt{‡Úü^f�©´¿Ýæñ¤ ¢.‡½ø»¿5 aN`ÍbR" Oñ6’£Ìt~§´½Òæú+/k²w*
;IàƒÔ|µ1ÛýQA  B ` ~ œ º Ø Loz�‘§³#-@„S^Îï!ì_g�Ôû = [ y — µ Ó =ˆš
Y™Í=N™u§¦�ªµ ‰�­µ	 ØdÞˆŒ¼ÀÞçò¥
 ào0Ú&O6BÛ á.Fu£~
ˆ�“–X{"¼Îc!  ñ 3>LÇ	
ñ
5�ã^6¡‹5aœ 	Ó/t¾œù½õÀbÞ‹ÐSs«+0 E N c � Š Ÿ ½ Û DP„”Ïò	7D[q“ÍÒu‰¨¾ÓçŸHt³*¾Æ„(	1	7	e
$‘—d µ,QqR”©G'
¬
Á
Ó
Ù
"„ÕN}š29> ­`·0l"Loì+
O
¨~8C‡þR V Î dŒº¤ûZ;x•È„
<Jaá¶µÃ÷ÜB 7 tÁå´.<mÔd	õ
*¾{êÏð.hÕü MôM	¸
{…jm_¤í`ï# C L a  ˆ � » Ù 7Ybpr{‚’¿ËÍþ@BYoä$ò(–˜Jž ¨ A�	[TO5"F' 9>[š±Û-PgªÃÙùG\kžÉÆöÞ¦	W
fšå>šú¨æH!6‘ ' ‰*A ~µ
Ê
x–Ñ(ëSv¤/ .|QZn£xEÝT)LVy ¶É¿ > \ z ˜ ¶ Ô Æà„ªÊ8ä›
ŸÎO§ç«Za  ŠÆ
Ùßç	òjß¦! l ÕêeÑx�‘ÃJ’£	¾
!>eÖV‰½X*ŠE-Áó[w€ j ¦ &íIg
GÖ,Ü	�ÿ`�ÌÕl¡ª }æ˜\’Â1<®´¶	
D\Ü´
læ‘›<º}è Œz¦m	¯
VbøË	 )Ö
]Ðº1' ß1Tkƒ®Çýo¢Ík™	
;ÛP7CnÜ * ðP¸—
ápã‚î%Cý  Øt¤	¾	`ÿ#Fs¬ìÏL CA£
Í
Ü
,3‰‘”—LVÙ½d" ?Z–¨µÄ/GvÄ
Y”|7,Hw
 7¦â±
T hö2  é ò {äÈà�¨Ÿ¯Ð� ªD9³>± 
ò
6ä_j,k¡ Ä â 4J?›é	
¢Œ6± R Ž %eMþ5\	ã
�F7õ�Úb�= 
™ó’	Ô	`
�JÏÄ7Iÿ$q T 4 Ë ¹ÀÎóWbƒ	{
�
©
0uÁ²cß·Ñt,/ p »ÔÏ#	Î	
¿Q—fÈ‹ ¬ ¼ŠÑ�¯	ò	ñú>¾ö?Œ˜z¬4  ô Ðó
\Î©¿ÔèÊ\u¿Ûd¿8	
Àçyü®Â‹$ O g m ‹ £ © I¯Á(Iê;Vn­æ²?�…�º)	A	
)-J: d   E8ES¡´+ÇÑR
%U{¨ÉÒI¥‚ö	’Ò7 F ‚ ¾ Ç Ü å "@Q]…•œ³r”�Ó7^v€Š æø3¨7·Êr2	u	‰	Ø	/
f
n
²óoX"}˜eß R¾•àÜâ
ù
#…‰�îO›ÂÕëyÆ? ;q-<ð‰ÑSªd 	
(
BV:ÖPŒ~#Oq ,Èr&J§¼Ô	HmÒb	³
 _²3:Ÿ! Ý/Ri�¬Åûm ¶Ë5¤‹'¤k	­	^
­
Â
Ô
Ú
á
Î#ªóÎÉ  s ë (¸1m¦%5Ïäó/pÁ		«	ä	é	P
Y
’
T]¾68³µGÌ ®ðÑ	qp†™9 ôˆS“  M#.íüR	,
‰
Œ
©û/@7ÛªßD†vÿ¤» aõM(™ÂTØùo±8  [o2Ã	…
œ¡õ1-Ô‚Õø$Ci V”âLéy�Éë	=�œâÎ·ß.ˆI¡• ü…£áðû1<–~	¨	æ	[
Kbh¯B‰·+èÄ@# W u “ Ï í *He�»¥ÛŽá}º–ìœ	#
”
~ªÇBï­â¶Ý‡– uµÛ1YÙ¿ˆ›;iÖ â=®î
8li¸YýÂ
 Â/ne	ö
ëÁÐñ 8 æ ÕV	+|*«ÌW/ õ"N	|ü?½x¿î• �
|Ðµ¹
†kr¡sx†�Ÿ`:aŽ§³¾ð1›£° N,åÌ‚˜ÓR»¦Í¥ œ~@ 2s�Žnâ!]ŠÏ* D M b € ‰ ž ¼ Ú cƒ‹“¬¹ÎCZp)§7™–ö K ‡ aqsÀÌÿ?Anñó;L	·
ô
z•—î & 8Z™°ÅÚOfø)F{ PemùwÜ£ 5KUŸ. |å%€³C=[ŒÛæ~UËW�‰,Z ) ‹j\Uaí
m >Y•B@¢
Ì
Egë6GK  ©CdI4®Ù° òV˜‘	Ó	ðIP–±6#p  Æ ä !?\›²6H]÷¾.
(æûz§H¤|IŠ  :Ü.Qh€«ÄúlŸÊ+Ç%¦ßÿa	íO±x"NÈ L	X
‹
S\pú?Ú©ÞFn7’£º ÚU„¢ë1ú§	"
g›› ô®Þî¬Ôáç	 0XU	)VXÁ +!ŽË—Ò>rw…º¥Ì9›¦²½Î0? zK	¶
Oly¦BZÚTV�ˆ•+4í ( ŠBË
H•ì°5­o¯ Tƒ0¥þ`	!
'R[oùóyÙÝGÓM¢¹‰ /T	Nk¥Êq„UŽ8®*WÍÀ ÔRS¤ÇÈÉø·¸ÕÖ×ØFpƒÇ­¡·¸ÊËÌ†‡ˆ ÕJ}«1±¹\uÞÈ³¾z ! �œ
Ï+d”¢šßÄ^Vƒ¬[ ? ] { ™ · Õ ¤á�…Ë9B
x
 ¬²Æcã¤´b ëOAˆ~H	h	?
]vL¨ÉèS¿ ÇÖKÅ«�×åöïß	Ž
ý2P²º9!o{   ÷ž^¸Ú$,e•›_Wà§
 1 c‹�
Ç
å
à„� � ÿ7ÎÙÃ	ý
Ä(*Ÿèàýók’	 " Ð£
Å­\ †‚þ7Æ	­³?fì�Ç)¾ÏYq¥.Â\c% @ ^ | š ¸ Ö m¥4†¡±Ê !r¥fÒyK	C
HçWŠ+ÜfôF�" T W×â‚ëFOÏ6:’Ä*“&	¤	U
¿
¡"(yLä�³åCF	<Ç îÌÖ	�	y
J’¦D×€9dGû‹µx k § î&:‰JH-›¸i	s	|	€‡!¨Ö ÊéÀ þ ='ï–¬h×ì
ŽÚ¡X  HPôI	Ý	@
ëM¯a«	Tm¢« ;ìBD �2^wŽ Í©d: 1çÃ=
r
EÄ:VÝµ’f»p ~ÈÆ]ƒOð	ø	Q³]»§òçO˜œ~)? ×Lc¬“2ž»Øa¯æ÷~µ�
34m…[c íú'yg™·	à	þ&`÷"=|éV  w_
¹æf°XÌ  Á ß !Þ]{§øŸn	²	b
—
cLœmùC¨  	÷`�yØ°
íð%:OW–ßù?ÏS` T›Üt
ÓÙÛ-3c·KúáÖ *Œ	9
æ
^6Ñ2;v1‘â dÅö»2]€ÛNÙ÷  ‡È
×
Ó(h…b½ 2 ™‹ž
áý<Íýô ‘ ßlÏÚ?	š	Ö	
‡
Å+mþô“8oÝ I … àlÎþ
÷Ÿ½™( éÃ  ž)¬µ Ä<áÜlQ¼™° 2U„¯Èþp£84Ä	éûDVT …Ñ×âäªï9&r®&:R ¹˜q?Åõqñz×�àt # G£® !ä/Erƒ¤Ñ„Æ&Dþs!<H + 3u™ñQ½V”	i
ÜÆXÖ”Æ(7E] h TX…x	…	Ç	ú	®´gs˜ $íÐ/]Md ‡äŽëÿ8 	�	»	aí-GèóQ|r2 . a	¹j{õ	?µ‘t’*­¿(žÉƒ€# ° ��šÙýuÙ`Ãƒ¥Ëç<	Y	\	¿	ôÊ@�ÈåÐZei›¦¹Ã! -:‘&DgÓBNcÆAzL÷	í	2
D
Î
Ý
Šè©á,ág#‚ »†©¤
-I…�Úº¾XKÊØâeäõG* < A Z _ x } – › ´ ¹ Ò × Kny€�¦ð5‡¢²Ë"s¦³ùvƒ˜ßM‹´0]Ó   ð }
4’•WßôŠÙ%Ý›A! U Í C_ž¶GPYQ“ÅF”Çë'	0	6	&
ƒ
«
À
#}M8B�´= 6 6X¾ÊýXãl)Zi½zé£-
I$ ,~©ÂØß@[j�Èƒ©Åõ7Ý¥	V
wž¢ä•ÐåæG(xÈY` —Ôéìd‘Ð0H;Fw+‘¢	Û	Å
Õåšñ¹D©v ï–y	˜	�¹:Bü÷ §´×s	2KSU“_Ø+v1 è $8ã²ßý[	§EiŒž�+j  Ê »¿ÍÐÎò‚	Í	z
€
ÃeÇH—¶Šy.3# l ¨ ó œ®Àå'É: Úc±>€œ¹t	
m
x±­È!ÑÁ £;Š½ïIcÑáj	
]
Í‹"©òêž  r ê 'ï¥4ãò'.˜Àûª	Ð	ã	è	‘
.5Á6S…²×°Ëu �|“áKàïèŽ}	€©Í0AÓ�ˆ-‡ #h ­Øí
7kh· ä´��\��}¢¯ % `Š˜«¸Ù>Ne÷(Eð:²ó
dåÊÛ¢-Y ÿ H—?i3¡
D`f	êlJ Å ã  5*K½êù	ìN°£
Ç yJ	GÙ¹¬nì> IQ‚_	 
Mj÷°[to�Æ7¬²   € @‡œÖõG	Þ	>
A
w

c™b]U£ � þ6Í]ØÂ	ä
#) ‘# S  ÖíENÎý6	%	€	I‘¥CGæx�(8ÎFŽÛBe;Æ  <C•«ÿ€·ë
1†®ªc ì&xf‚º	
q
Ã%3_¦öN—Ze> vÝš±	
a
s
–
ìbKÞø¶Jl¯Õ Ä˜Š8
ü;Ìug Ú¼	 èŸÕ	žÃú¼U˜ 2˜„¼>Uô“	ÖF­©ÅDWÐÅ8“€%rßq69G  - ¯ gŸSŒü„¸„	Œ	º	ô	ù	ó´ÉŒ—‘'Pdh�È¸ ; Y w • ³ Ñ ï ,J�ï�u¨|
ÞÞ¨ó³$àšÒ@- 5 Ì 5W½Éü+}¨ÁÞiœÇ^k�ÓôXc�Pê/	5	¡	%
‚
ª
v¼è™äA¸uX_ #º¾ÏxüZñ	—	Ì	1R^ÂA*Ž‰*i-0  q &›­¿¼3ŸÙîb°ç&ÐÏ	â	
l
�
4wÀÌ5@Rñ† ‰·ØMdöã€[gÉŒ|® ¼Õø ZbØ˜n\ë  ëw”¶	$	
ê
(–d —ƒÜžT°	7
ë¬ûÂË÷ù~»5  ® îû*|§½Ýh›j‹Òû�Y–	 	¹	Ë	ó	ò&@#@�™hW %ˆ¶êõá	k
ÿË'?aê{­ ­ é()z{óôšiŽSXž	Ÿ	¸	ÈÉÊ¿ÀÁø%>?}¹º  +Ä  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 	                                                                                                                                                                                                                                                                                                                                                          	                                                                                                             	                                                   '               
                        	                                          	         	                                 
                     !   r   g                     T   
                                                                                                                                                                                                                                                                                                                                                                                                                                                         	                                                                                                                                    	                                       	                 '     
        	              	   	           
       ! r g       T 
  fý  gõ  h  hW  kÇ  oÍ  u1â<‚	jÉëï3ŸÕ¸Xó	l
ÞŒžD[G½	ô�5�8Ël	ñ	ïLý‰ÎVŽ–k^‹ù7°K
é À Þ +VŽ–†u™¹Ä×àÁ	Òv¢ö9«çkØö;=^/	Þ‰^äº®	½	ô>º®	½	L
ôº®	½	ôºº0	¥	«
ñ�÷l
—/5z^°)u	5	Ì	þ	_½
Òœ_nÂi ¥ I½
	¯œã
à
à
ƒ	¸^ï	­°‚ÒÁ	f_ ¬¯~ø	¬¯~ø	¸^ï	K	¶
yíþ	0S‚­Æün¡0 ý oÃÕiw	îb×È 
Fs”g
Úî|Å”F7@ýÚOTœr2	‰	ÓÛ}™
X©´ïc‹£˜	0Ss‚­ÆüOn¡g
Úµ|
±¶?”¶”]7
ä
è*–Ñ¤›	è¶”œr2	‰	ZËè¶Æ
� ÍØ)‘sg
ÚóÆMDHò Èó	&:áèó
…DêJsg
Úþp
eª È 
FøsZø”¸†ð	g
o
Úèî|šÁÅ#Lm”©µ®±>œ¹‚Nì	æe h9_<j˜	mS�x¼Ùb/	5	Õ	
8
k
Öw:�`
JÝ²ø/Ø¥	å™IÔÓ® ‹ûò¬“ Ó%Íhý�/	5	±Ë›	è¶?”¶O’¿
L<µ|�¼/	5	  –‚Þ%•íÆö	«È5‹°àgÔÿ�x/	5	Õ	Ö�µÆ|h ¤ ZÀeý^jj{†ai>‚ß§žÖq„8¿ Ý 1ÄV’®ï±>cœ¹‹‚N£�Y	åàïˆ™
áX0 �'0 ý Ðå

�¶ž”(9pk § &Of¬y‹’K›¸ÙC
¿
ì
¸eëM¯LO<˜:ò?öÔ�ÙÖÊÐÅrtä
áè�Ê0 	ä
æìe�þÿ»Ð—$_Â<b“×8  sÏ*]•’¬ì
h ¤ jZÁý^j[Á	³	k;|gŸ›S­¿„ŸÙb°„	ù	
l
w—:9_<Œ�’™Ø_ÂßÊæ;	X	[	Ì/Òä,š"g n ª #†´øa•·�ùœ¹_É	ð	
5
èé#rƒafvÜ°	
ë÷¯3‡¢Ò
±
ÓÄÌ�	y
dGµxn ª øa·¹_ð	
ƒa�™Ø_ÂÊæ;	X	[	äšŒ’ßÌ/Ò,"gÓc�¡	™¸uÑˆs½ƒd
cb—SŒ�’™»ØÛ_ÂßÊæ;	X	[	ÒÕØÌ/2¨CÒä,šùÞ"8FggŸ›Sv­¿Ü„ŸÙb°„	°	ù	

l
ëw—÷¯èE�Ú	Ôð¨:`Âò äÈÐ- ¸ô	´‘'�ÈÐo ‚c
Ñ
—‘0;åš¹ý6�(Î½á
êx®ùU é ŒÔ	¯
V�s¬¯T½ý6á
�(Îê	¹j?*¿(ƒè ãß§žO·â$3S—ƒT¬5 åÿQ � É�ãp	´	â
ú
×cïô&<áû †:‰Ã÷Hžþ7i	ì:›!¨fqé§Õb˜\
 KôÉü\kïeG
noÓê14&£	¬	à
rá ”¯ú4Í‰)ñ	ï ôÝ	@
aT¢p	ú
ï&Q � â
ô<4&£	¬	à
úÍÉ�ã´	×cS»ÛÒÕØ2¨CùÞ8Fè ã	ß¹j?§*¿(ƒž,R©'
Õ}á�9 ãz¦m	øç»…Ñ×âäªï9&r®&:R2˜„¼>Uô“	ÖF­©ÅDWÐÅ8“€%rßq69G À Þ Sö_x×\ÛÒØåï29N>ÎRùBÿ=Xc”ñUÒ	ïØ(F‘þ€íÖù]	À	~õ,‹ËA#}«¬µXÄÅtpÄh
Û¢ãÿ .qÕƒðyÖ's%;DQj­Øí
7kh· i ¥ k[Áf	ÂÕI½
	³þ	_kÔ);ik|  #U†�´•�ùœ¶s3	Š	É	ÿ	5
ÔéÜŠ•§Y#s~ØfvÝš±	
a
s
–
ìbKÞø¶Jl¯ÕU Í C_ž¶GPYQ“ÅF”Çë'	0	6	&
ƒ
«
À
#}M8B�´= 9 ± #U^†–�´ç!•žÔ�‹(Fgt‘›¡Úùþ4v€œ©Ìíú8w¸Þ¶Ë$Qasˆ¦¾Ößèù	-	3	E	]	Š	À	É	ÿ	
5
<
o
u
è
~Ôéõ,`u‹ËÜ.AŠ•§Á#}«°ÉYd�¬#LfjsµX~ÄØf·ÅÓf6 D K M U b € ‡ ‰ ž ¼ Í Ú 6CXacqsƒ‹“¬¹¾ÀÊÌÎýÿ?ACXZnpãñó;_lž¶GPY)Q“ÅF”Çë'	0	6	L	&
ƒ
«
·
À
ô
z§#)Zi}½z7M•—™é8B�–£´ö-
=Iîß1Tkƒ®Çýo¢Ík™	
;ÛP7CnÜV”âLéy�Éë	=�œâÎ·ß.ˆI¡•= [ y — µ Ó =ˆš
Y™Í=N™u§¦�ªµ ëw”¶	$	
ê
(–dø ­ëæ©–¡´¼ÝãC	ý		
:
ºÃìï3Ã’+!ŽË—Ò>rw…º¥Ì9›¦²½Î0?p ¡ß1Tkƒ®Çýo¢Íì(2F‘þ€»çíPk†“ªÔ^¢ñÏÖù#	]	y	†	™	À	Î	

~¯»Äõ,‹¿ËAð#Q}‰œ«4—¬;fÈµÛXP‹Ä7Cn“ÅÜ1 c‹�
Ç
å
à„�   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ù<?xml version="1.0"?><Features nextValidID="15"><Feature recentID="0" name="PKM2" directionality="1" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1121-2713" color="#ccffcc" type="standard"/></Feature><Feature recentID="1" name="CMV IE94 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="52-1036" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;enhancer/promoter region of simian cytomegalovirus major immediate early transcription unit IE94&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5064" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="4273-5064" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5065-5133" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3514-4102" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="f1 ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5264-5719" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="SV40 poly(A) signal" type="polyA_signal" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2826-2960" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5134-5238" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="3xFLAG" directionality="1" translationMW="2730.72" type="CDS" allowSegmentOverlaps="0" cleavageArrows="2785" consecutiveTranslationNumbering="1" maxRunOn="2788" maxFusedRunOn="2788" detectionMode="exactProteinMatch"><Segment range="2720-2785" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;three tandem FLAGÂ® epitope tags, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="DYKDHDGDYKDHDIDYKDDDDK"/></Q></Feature><Feature recentID="8" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="3160-3166" color="#ffffff" type="standard"/><Segment range="3167-3184" color="#ffffff" type="standard"/><Segment name="-35" range="3185-3190" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3205-3226" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SP6 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1071-1089" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage SP6 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="T3 promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3073-3091" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T3 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="T7 promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2804-2821" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3112-3128" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3136-3152" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  §<Notes>
<UUID>20a2d88d-0da5-46d4-a6eb-0cfe52bb1436</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pCS2-CMV-PKM(human)-3Ã—FLAG</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="6:35:50">2019.1.17</Created>
<LastModified UTC="22:9:31">2025.8.26</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y     K         
?????                                                                                                       ÿ d      HO  d               E              ÿÿÿÿYô? P                                                                                                                                                              3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
